Enhanced Inflow and Outflow Rates Despite Lower IOP in Bestrophin-2-Deficient Mice

Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice.

PURPOSE Bestrophin-2 (Best2), a putative Cl(-) channel is expressed in the nonpigmented epithelium (NPE). Disruption of Best2 in mice results in a diminished intraocular pressure (IOP). Aqueous humor dynamics were compared in Best2(+/+) and Best2(-/-) mice, to better understand the contribution of Best2 to IOP. METHODS Measurements of IOP, episcleral venous pressure (EVP), conventional outflo...

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

Impaired regulation of hepcidin expression in response to iron loading appears to be the pathogenic mechanism for hereditary hemochromatosis. Iron normally induces expression of the BMP6 ligand, which, in turn, activates the BMP/Smad signaling cascade directing hepcidin expression. The molecular function of the HFE protein, involved in the most common form of hereditary hemochromatosis, is stil...

BMP / Smad signaling is not enhanced in Hfe - deficient mice despite increased

Experiments on the effect of inflow and outflow sequences on suspended sediment exchange rates

In laboratory experiments, the influence of inflow and outflow sequences on the behavior of fine sediment was investigated. The experimental set-up consisted of two interconnected rectangular basins, between which water was moved back and forth. Suspended sediment concentration in the main basin as well as the sediment exchange rates were derived from turbidity measurements.The suspended sedime...

Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression

Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron, biliverdin and carbon monoxide. HO-1 deficient mice suffer from chronic inflammatory stress and delayed cutaneous wound healing, while corneal wound healing in HO-2 deficient mice is impaired with exorbitant inflammation and absence of HO-1...